Preparation of Zidovudine Extended Release Matrix Tablets with Various Controlled Release Polymers: A Feasibility Study of Granulation and Compression

The matrix tablets were prepared by using Eudragit L 100, Poly ethylene oxide and Carbopol 971 P. The granules of Zidovudine using above polymers were prepared by direct mixing, wet granulation with water and wet granulation with IPA. The granules were characterized for the morphological study, bulk density, tapped density and particle size distribution. The granules were compressed in to tablets. The tablets were characterized for in vitro dissolution, DSC and FTIR. Different shapes of the granules were formed with the wet granulation process with different polymers. In vitro dissolution studies showed the prolonged release of the Zidovudine with these polymers. The drug release depended up on the type of polymer and granulation process. DSC and FTIR studies showed no drug polymer interaction. This study gives an idea about the feasibility of granulation process for the preparation of the Zidovudine matrix tablets with different polymers.